1. What is Rheumatic fever? Rheumatic fever is usually seen in children between 5 and 15 years where, after an episode of fever and sore throat, child again develops fever, joint pain and joint swellings along with heart disease. There is a strong relationship with the throat infection caused by the bacteria Streptococcus.
2. What kind of children develops rheumatic fever?
3. How does sore throat predispose to rheumatic fever?
Not every child with streptococcal infection of the throat develops rheumatic fever. Some children are genetically susceptible. The antibodies (molecules produced by the body to counter the infection) produced against streptococcal bacteria unfortunately react with the heart muscle, joints and sometimes the nervous system resulting in the manifestations of rheumatic fever.
4. What is the clinical picture of rheumatic fever?
At the onset, please remember that all the manifestations of rheumatic fever may not be seen in a single patient. Diagnosis is often made with the help of certain clinical features and other laboratory investigations.
The main clinical features consist of heart disease, arthritis (inflammation of the joints), chorea (purposeless jerky movements), subcutaneous nodules (swelling seen beneath the skin) usually seen on bony prominences like elbows, shin, back of the head and spine which are non tender and a peculiar rash (erythema marginatum). The rash is faintly reddish, non-itching, which appear as a red spot or as serpigenious. But it is difficult to recognize the rash in Indian children due to the dark complexion of the skin.
Patients who have subcutaneous nodules almost always have heart disease. In India, these swellings are seen only about 5% of patients.
5. How does rheumatic fever affect the heart?
Rheumatic fever affects all the three layers of the heart (pericardium, myocardium and endocardium). It is seen in 50-75 % patients of acute rheumatic fever. Almost 80% of the patients who develop heart disease do so within the first two weeks of the onset of rheumatic fever. In pericarditis there is swelling of the pericardium covering the heart and fluid collection beneath the pericardium. Myocarditis leads to heart failure. In endocarditis, the heart valves are damaged and results in rheumatic valvular disease. Rheumatic valvular disease can be long lasting and it can even cause death of the patient.
6. What are the special features of joint pain due to rheumatic fever?
Knee joint, ankle joint and elbow joint are the commonly affected joints. Rarely smaller joints like joints in the fingers and toes are also involved. Because of the pain and swelling in the joint it is difficult to bend and straighten the joints. 50-70% of rheumatic fever patient’s joint problems are seen within the first few days itself.
7. What is this abnormal movement called Chorea?
Chorea is a late feature usually occurring 3 months after the onset of rheumatic fever. The affected child is emotionally disturbed and drops things he or she is carrying and also there is a deterioration of handwriting. This shivering spontaneously disappears in 6 weeks.
8. Is it necessary to do blood test, E.C.G., Echo test?
Yes. ASO, ESR and WBC Count are elevated. ECG and Echo test are necessary to find out the status of the heart.
9. What is the treatment of rheumatic fever?
Complete bed rest is advised for some period. If there is heart disease, restrict salt intake. Drugs like Penicillin, Aspirin and Steroid are used for the treatment
10. How can we prevent Rheumatic fever?
Do not ignore your child’s sore throat. Consult your doctor. Proper treatment of sore throat can go a long way in preventing the first attack of rheumatic fever. Once the child develop rheumatic fever penicillin treatment is a must because it prevents the development of heart disease due to rheumatic fever.
11. How long does the penicillin treatment to be continued?
(a) Rheumatic fever, no heart disease
Penicillin treatment for 5 years from last attack or 21 years which ever is later.
(b) Rheumatic fever, had heart disease but now there is no sequelae.
Penicillin treatment for 10 years or till 25 years for the child which ever is later.
(c) Rheumatic fever, rheumatic heart disease existing.
Penicillin preferably life long or at least till 40 years of age.
11. Does penicillin treatment has any side effect?
Penicillin injection some times produces pain and fever. So it is better to take injections on holidays. Rarely penicillin injections produce severe allergy and sudden death. But parents should understand that such allergy is very rare and if penicillin is not used, heart valves of the child will get severely damaged. So before every penicillin injection test dose is taken. But test dose may be negative and allergy can come on injection. So any allergy is noted and parent should be immediately reported to the doctor and it requires emergency treatment.
Tablets can substitute injections. Penicillin tablets 250 mg two times a day to be taken and to be continued irrespective of the age of the patient.
12. Is there a chance of infection to heart valves due to rheumatic fever?
Definitely yes. There is increased chance of infection to heart valves in those with rheumatic fever than those without it. Due to rheumatic fever, infection can occur to normal heart valves and those with heart disease at birth.
(1) What are the symptoms of infections to heart valves?
Prolonged fever, reduction in weight, body pain, joint pain, head ache etc. The efficiency of the heart decreases. Spleen enlargement, red spots appearing in the skin, bleeding inside the brain, pus inside the brain, paralysis of the body parts can occur.
(2) How does a heart valve get infected?
Usually after dental extraction or after dental surgical treatment, heart valves can get infected.
(3) Does this infection has treatment, if so, how long?
Yes. At least 6 weeks treatment is necessary.
13. How can we prevent this disease to heart valve?
Those with rheumatic heart disease should have their teeth very clean. Very good personal hygiene. Inform the dentist about your heart disease. And while treating dental problems, a good cover of antibiotic treatment is necessary to prevent infection to heart valves.
14. (1) How does this heart valvular damage occurs?
Mainly the mitral valve connecting the two left sided chambers of the heart and the aortic valve connecting the aorta with the left side of the heart are involved. These diseases are called mitral stenosis (constriction of valves), mitral regurgitation (enlargement of the valve ring producing leak of blood while the heart pumps), aortic stenosis, and aortic regurgitation respectively.
(2) What are the symptoms for the child if the heart valves are damaged?
In the beginning there need not be any symptoms. But once the disease progresses, child will develop tiredness, breathlessness, palpitation, difficulty in playing etc.
(3) What treatment to be done once heart valves are damaged?
Once rheumatic fever comes (even if there is no heart disease) penicillin treatment should be continued to prevent the recurrence of rheumatic fever. Recurrence of rheumatic fever causes severs heart valvular damage. Dental treatments should be done under antibiotic cover to prevent infections (infective endocarditis). If the heart function is poor, drugs like Digoxin is necessary and anemia (pallor) should be prevented.
(4) Is surgery is necessary for heart valvular damage?
Surgery may be necessary when there are symptoms like sever tiredness or breathlessness or when heart function decreases irrespective of treatment. Surgery is mainly Valvotomy or valve replacement. Balloon treatment for valve construction is now available and is cheaper nowadays.
(5) Can a child with heart valvular damage go to school and play?
A child with good heart function can go to school, play like any other child. But penicillin treatment to be continued.
(6) A Girl child had rheumatic fever— can she get married, get pregnant and deliver?
If there is no heart valvular damage, there is no problem for marriage or delivery, but penicillin to be continued. If heart valves are damage, special care should be taken during pregnancy and if there is no severe damage to valves, pregnancy can be continued. But delivery for such a lady should be in a hospital with all the facilities. Mitral stenosis can be corrected before pregnancy through surgery. So a lady can undergo surgery and then get pregnant. But somebody who has severe damage to heart valves, better not to get pregnant as during pregnancy or delivery heart disease can get worse or even death can occur.
If your child is having any symptoms of rheumatic fever, consult a doctor, take treatment. If you are careful, no need to get worried.


